In Alba, Piedmont, Italy, with Asger Jorn and Pinot Gallizio, Piero Simondo founded the Laboratory of immaginiste experiences as part of the International Movement for an Imaginist Bauhaus (IMIB).

He edited Eristica the magazine published by IMIB and September 1956 he organised the First World-wide Conference of the Free Artists, with Jorn, Gallizio and Elena Verrone. He married Verrone two years later. At the Cultural Union of Turin he helped put on a demonstration unitary urbanism in December 1956.

In the summer of 1957 he took a holiday in his house in Cosio d' Arroscia. Here, with Michèle Bernstein, Guy Debord, Pinot Gallizio, Asger Jorn, Walter Olmo, Ralph Rumney and Elena Verrone the Situationist International was founded on 28 July.